Tuesday, September 28, 2010

Review of "A Finding on Malaria Comes From Humble Origins"

Claudia Nagy 9.29
Chem 2 H/ Block D Even Mr. Ippolito

Jr. McNeil, Donald "A Finding on Malaria Comes From Humble Origins" New York Times~. 28 Sept 2010. sec D: 5-6

This article by Donald McNeil Jr. explains how Dr. Beatrice H. Hahn has discovered that one of malaria's most deadly strains actually originated from gorillas, and not chimps as previously thought. As a virologist, Dr. Hahn has been collecting great ape skate for ten years, accumulating 2,700 samples. She specializes in malaria was well as S.I.V (Simian immunodeficiency virus), the antecedent of HIV in humans. The samples are put into a solution called RNAlater which preserves the cells's nucleic acids. This leaves reveals not only the diet of the ape, but the cells that are scraped from their gut lining, which include all of the substances that make them ill. Though this new knowledge of malaria's gorilla origin will not lead to a new pharmaceutical success, it is reassuring to know that the human strain of the disease probably crossed species about a thousand years ago, showing that if malaria is every completely irradiated it will never occur again at the cause of apes. It was previously thought that chimpanzees were the original catalysts for malaria's most deadly strain, the falciparum due to the fact that they are human's closest relative. It was never known that gorilla's were the true initiators because the few gorillas tested were those kept in human captivety, and they often had the same strains humans near by had. With new samples that come from wild gorilla's skat, it has been shown that the virus actually originated in chimps. Dr Hahn retrieves the samples by tracking groups of bonobos or gorillas until they nest for the evening. In the morning, she returns and collects the samples that are left in the often obsolete nests, maintaining as little contact with the animals as possible.

I chose this article because it is important to society and relates to chemistry. Malaria is a deadly disease that kills millions of innocent people a year, though there are plenty of drugs and immunization methods that could be implemented to prevent its spread and effects. Malaria is particularly common in parts of Africa because of its climate, which facilitates armies of hungry mosquitoes, who are inevitably carriers of the disease. It is so hard to treat malaria in parts of Africa for three main reasons. Immunization is expensive for many people in those parts of the world, thus more people are likely to become infected. Additionally, it is difficult to avoid mosquito bites, those of us who live state side have problems avoiding them even in our front yards. And though most mosquito bites could be easily avoided with mosquito nets or repellent, those luxuries are also scarce in parts of less developed countries. Finally, the sheer number of those infected with malaria is so high, that hospitals have trouble treating those who have already been admitted, let alone new patients who require care everyday. This article relates to chemistry in many ways. Chemistry was used to preserve skat samples and ascertain their composition, as well as their relation to malaria. Chemistry was also used to discovery malaria vaccines and treatments which have saved many lives to this day.

The article was formal and informative, which in scientific essays is both pleasant and obligatory, however the article was lacking in the most fundamental component of scientific essays, which was scientific evidence. There was little explanation of the science of malaria, its chemical composition, how it worked, or how it was spread from gorillas and not chimps as previously thought. It seemed somewhat loquacious, yet lacked any real substance with which to prove its important points. It also focused predominately on Dr. Hahns, who though is surely an interesting individual, is not the subject of the essay.

2 comments:

Andrew R. said...

Andrew Reichel

The review of the article “A Finding on Malaria Comes From Humble Origins” was very interesting. Malaria was originally believed to come from chimpanzees, but it actually originated from gorillas, as discovered by virologist Dr. Hahn. The summary of how Dr. Hahn found what caused the virus provided interesting scientific background. The human disease came from a mutant parasite that crossed over from a single gorilla thousands or more years ago. The fact that these experiments can be conducted on a single fecal sample with a complicated setup was unexpected. I also learned that the sample must be kept uncontaminated, since the bonomo that was exposed and contracted human malaria also contracted resistance to the malaria drugs. I found it fascinating that the bonomo caught malaria from humans and not the other way around.

Malaria is an important subject. This article contained many interesting concepts, but jumped from one topic to the next. I would have liked to have learned what makes one form of malaria more deadly than the next.

Learning that malaria kills millions of people was shocking. This is an extremely important article about malaria and how it is transmitted.

Max said...

I really enjoyed Claudia’s reflection as a whole, I felt that it was written in a way that is comprehendible on a topic that is hard to grasp. I also thought that it was good when she described what the virologist’s background was. Another part that was very good in this reflection was how she referenced it to pharmaceutical industry; even though it wasn’t going to be connected she still mentioned it and said there would be no benefit in that industry.
At one point Claudia says, “this leaves reveals” which isn’t grammatically correct and needs to be changed. Also, she goes into a bit of too much detail on the chimpanzees that weren’t necessary for describing the article.
I found it very interesting that chimpanzees could have caused malaria, which seems unfathomable because it seems so weird, but humans and chimpanzees often have the same strains.